Development of effective vaccines for enterotoxigenic Escherichia coli
نویسندگان
چکیده
منابع مشابه
Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli
Enterotoxigenic Escherichia coli (ETEC) are a leading cause of diarrheal illness in developing countries. Despite the discovery of these pathogens as a cause of cholera-like diarrhea over 40 years ago, and decades of vaccine development effort, there remains no broadly protective ETEC vaccine. The discovery of new virulence proteins and an improved appreciation of the complexity of the molecula...
متن کاملStatus of vaccine research and development for enterotoxigenic Escherichia coli.
Enterotoxigenic Escherichia coli (ETEC) is one of the most common bacterial causes of diarrhea-associated morbidity and mortality, particularly among infants and young children in developing countries. Still, the true impact on child and traveler health is likely underestimated. There are currently no licensed vaccines for ETEC, but studies indicate high public health impact, cost-effectiveness...
متن کاملIdentification of Enterotoxigenic Escherichia coli
Alkaline phosphatase-conjugated (AP) 26-base oligonucleotide DNA probes were compared with the same probes labeled with y_32p for the identification of heat-labile (LT) and heat-stable (ST) enterotoxigenic Escherichia coli (ETEC). The AP oligonucleotide probes were as sensitive as the radiolabeled (RL) probes in detecting LT and STA-2 target cell DNA, but the AP ST probe, which differed from ST...
متن کاملEnterotoxigenic Escherichia coli--an overview.
Enterotoxigenic Escherichia coli is an important cause of traveler's diarrhea and diarrheal illnesses in children in the developing world. In this presentation we will focus on the main virulence attributes of this pathogenic category of E. coli, and discuss the evolution of studies conducted in our laboratory.
متن کاملFrom cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development
It was shown earlier that immune responses against cholera toxin (CT) as well as Vibrio cholerae lipopolysaccharide (LPS) or whole bacterial cells (WC) were protective and that these different antibody specificities co-operated synergistically for protection against experimental cholera. Similarly, antibodies against the heat-labile toxin (LT) and major colonization factors (CFs) of enterotoxin...
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ژورنال
عنوان ژورنال: The Lancet Infectious Diseases
سال: 2020
ISSN: 1473-3099
DOI: 10.1016/s1473-3099(19)30631-0